Kratom and Suboxone: Can They Be Combined?

Kratom and Suboxone

Most people who have come across or had a chance to use Kratom and Suboxone get confused with the products. Some even claim that they are both similar.

Well, both products share some common characteristics, even though they are completely distinct. This has led most users into believing that when they are unable to acquire either Kratom or Suboxone, they can use any product between the two as an alternative to what they desire.

While it is a brilliant idea in case both products can help you achieve your desired effect. However, it is vital to understand how both Kratom and Suboxone work.

In this article, we have detailed more about Kratom and Suboxone to help you understand the relationship between the two products.

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What Is Suboxone?

The brand-name prescription medication Suboxone is used to treat opioid addiction. The product is a schedule three (III) controlled substance. Suboxone is made up of two components, including opiate agonists Buprenorphine and opiate antagonists Naloxone.

The product is available in a generic form, which is normally available in two formats, including an oral film and tablet. Users can consume the two forms by placing them under the tongue.

Suboxone and Kratom Have a Symbiotic Interaction

Kratom contains over 40 alkaloids, which are nitrogen molecules that act as opioids. Among these alkaloids, 7-hydroxymitragynine and Mitragynine are the most active chemical compounds behind most benefits of this natural product. The alkaloids offer users opioid-like effects by acting on the mu receptors in the brain. In addition, the two alkaloids function as partial mu receptor agonists. However, it's important to source Kratom from reputable vendors, such as the best kratom distributors, to ensure quality and safety.

The effects of these compounds depend on the dose. Kratom has a slight stimulating effect at low doses under 5 grams, which makes sense given its coffee plant heritage. If you increase the dose to between 5 and 10 grams, you may experience profound opioid-like effects, such as sedation, pain relief, and euphoria.

Suboxone attaches itself to the mu receptors. In comparison to most other opioids, this product binds strongly to this brain receptor. No other molecule can occupy the mu as long as the buprenorphine molecule does. As a result, other opioids cannot be metabolized and the recovering addict can’t take them.

And due to Suboxone’s preference for the mu receptors over the alkaloids found in Kratom, it is logical that it blocks the drug. Due to the presence of buprenorphine molecules in Suboxone, Kratom alkaloids cannot bind to the mu receptors and hence the user will not experience any opioid-like effects.

How Closely Do Kratom and Suboxone Resemble One Other?

The similarities between Kratom and Suboxone may rapidly be drawn from numerous features of the products, such as their appearance, use, and side effects. The following are some of the product’s similarities:

They both treat opioid withdrawal

Those addicted to narcotics such as cannabis and heroine should utilize Kratom and Suboxone. Most people who desire to stop depending on such narcotics, turn to either Kratom or Suboxone to help them overcome their addiction issues. However, you should exercise caution when mixing the two medications because a potent Kratom strain might cause Suboxone withdrawal, rendering the drug useless.

They are both addictive

If used frequently and for a long period, Kratom and Suboxone, like any other drug, may cause addiction. Consequently, they need to be used with extreme caution in order to avoid addictions. No one desires to be dependent on any substance, but the issue is the slower rate at which dependency develops. It is upon users to ensure that they do not become hooked. It is upon users to ensure that they do not become hooked.

The two products offer pain relief

The majority of people who use Kratom and Suboxone do so to relieve moderate to severe discomfort. The two products have been utilized as natural treatments for chronic pain and various problems for many years. Due to their opioid-like properties, the trees from which the substances are derived are used in the production of painkillers. As a result, a person who takes Kratom for pain treatment can safely utilize Suboxone for much the same reason.

Differences between Kratom and Suboxone

Since the two products are distinct, experts do not recommend using them together. Use Kratom as an independent product and not as a substitute for another substance. That should also apply to Suboxone. Mixing the two products can result in adverse effects even at small doses. The following are some of the differences:

Suboxone induces mood swings, but Kratom improves mood.

Another most noticeable variation between Kratom and Suboxone is seen in users themselves. A Kratom user tends to be happy and talkative a few minutes after consuming their preferred strain. Even though no one is paying attention to what they are saying, they do not remain silent.

Suboxone, on the other hand, is not in this category. Users of this product claim that they experience a wide range of mood changes. After consuming the product, the user can be pleased with one point and then be depressed and want to bash people up the next.

Suboxone has the potential to induce back pain

Most consumers report that back pain is one of the Suboxone side effects, even though Suboxone and Kratom are pain relievers. As a result, do not be concerned about back pain when using Suboxone for any reason. Fortunately, this side effect does not last.

On the other hand, even at higher doses, that is not a Kratom side effect. As a result, if by any chance you experience back pains after consuming any Kratom product, you should seek medical attention immediately.

Can You Take Kratom With Suboxone?

Mixing Kratom with other substances such as alcohol and tobacco can be harmful. However, when it comes to mixing Kratom and Suboxone, there is not enough medical justification of what users may experience. As per the molecular processes of the two products, both are opioid agonists that function to stop or prevent opioid receptors from responding effectively.

If these agonists combine, they can potentiate each other. That means that their activity would be improved as a result of their interactions. Although this may appear as if the products might work much better to reduce opioid receptors within the user, there is a risk of respiratory collapse as a result of the suppressed functionality. However, since respiratory collapse is not a foregone conclusion, it is nevertheless a potential.

A sensation of euphoria is a more common adverse effect of combining Kratom and Suboxone. When you get this high, the objective of opioid receptor agonists is defeated. Researchers claim that Suboxone has shown to be beneficial by itself, even without the euphoric high associated with Kratom and acute withdrawal. When you blend Kratom and Suboxone, its ideal functionality can reduce or even become life-threatening.

Does Suboxone Block Kratom?

Yes, it most likely would, to some degree. As mentioned earlier, Kratom packs a wide range of alkaloids that activate the brain’s opioid receptors. The product also helps combat opioid withdrawal, something it would not be able to accomplish if the product did not have some affinity for the mu or MOR opioid receptors. The human brain consists of three primary opioid receptors, including the Kappa, mu, and delta. The mu receptor is linked to euphoria, pain alleviation, and opioid withdrawal.

Suboxone comes with a synthetic opioid blend of buprenorphine and naloxone-based, which interacts with the mu opioid receptor. Buprenorphine is the opioid component of Suboxone, which is just a moderate mu receptor activator. That is why, when you consume the product orally, it rarely offers a euphoric effect, especially when contrasted with comprehensive mu receptor catalysts such as fentanyl and oxycodone.

Buprenorphine inhibits opioid drug cravings and withdrawal symptoms by activating the mu receptor well enough. It also takes a long time to act. Such characteristics make Suboxone an effective medication-assisted treatment (MAT) option.

Kratom and Opioid Withdrawal

For thousands of years, natives in Southeast Asia to deal with opioid withdrawal effects used Kratom. Even in recent days, most people in the West consume that natural product for this purpose. Kratom is very effective in that most former opioid addicts flood online platforms including Reddit praising how the product helped them quit using drugs.

Most people across the United States are hooked to opioids not only for the product’s effects but because they are frightened of going through the withdrawal phase. When going through opioid withdrawal, you experience adverse effects such as nausea, vomiting, headache, sleeplessness, bone and muscle pain, restless leg syndrome, backache, cold and hot flashes, as well as shivering. Most addicts would prefer to continue taking what they are addicted to than experiencing such withdrawal symptoms.

Fortunately, Suboxone relieves unpleasant symptoms most of the time, but the product can be addictive, causing a similar opioid withdrawal crisis as other opioids. A few users even claim that the withdrawal symptoms of Suboxone’s buprenorphine are far worse and can last considerably longer. However, most Kratom users on various Kratom communities report that Kratom consumption helps manage symptoms of withdrawal for as long as they need to and eventually quit using opioids entirely.

Effects of Taking Kratom to Help With Suboxone Withdrawal

Suboxone comprises opioid medications like buprenorphine and naloxone. Similar to other opiates, this product can also cause addiction. The substance acts as the brain’s opiate receptors, causing euphoria and a pleasant sensation, although not quite as strong as other opiates. Suboxone effects tend to desensitize receptors, necessitating higher dosages.

The product’s withdrawal symptoms are similar to other opiates. They include; muscle discomfort, watery eyes, runny nose, diarrhea, shivering, and vomiting. When you experience such adverse effects, begin working on the consequences right away.

How Can Kratom Help With Suboxone Withdrawal?


Additionally, Kratom serves to alleviate stress by activating GABAergic circuits, which prevents the body from becoming hyperactive. The product also causes analgesia by boosting the production of enkephalins and inhibiting pain pathways.

Effects of Withdrawal

Kratom and Suboxone influence the opiate receptors. As a result, you can use Kratom to help alleviate Suboxone withdrawal symptoms. Since Suboxone boosts the amounts of dopamine and adrenergic neurotransmitters in the user’s body, Kratom lessens the intensity of withdrawal symptoms like pain, fatigue, and a runny nose.

Ill feeling

Kratom consumption produces a euphoric mood, which helps to alleviate the symptoms of Suboxone withdrawal.


Suboxone withdrawal causes sleeplessness. When you consume red vein Kratom strains at a moderate dose, it can help combat insomnia. Therefore, quality Kratom can help deal with Suboxone withdrawal symptoms in various ways.

  • Kratom dosage to help deal with Suboxone withdrawal
  • When determining Kratom dosage, experts consider various factors, including:
  • The person’s physical characteristics
  • The health of the individual
  • Previous records of Kratom dependency
  • The consumer’s anatomy and physiology
  • Addiction intensity

Given the aforementioned considerations, the more serious the ailment, the larger the dosage required. If you are consuming Kratom in tinctures or extract forms, start with a lower dose. If you prefer the powder form, limit the dose between 3 and 9 grams. Doses of 5 grams or less will boost your energy levels and offer a euphoric mood. When used more than 5 grams, it serves as a sedative or an analgesic. Consume the product after every 5 to 6 hours.

User’s Opinions on Kratom and Suboxone

Regardless of whom you speak with, you will hear a variety of opinions and views about Kratom and Suboxone. Most users support using Kratom to help quit Suboxone. While others, recommend using Suboxone to help with Kratom withdrawal. Everyone has alternatives that work to their advantage or disadvantage. However, these choices cannot be similar for everyone, based on their circumstance and aspirations.

Final Thoughts

Taking Kratom and Suboxone at the same time can lead to a wide range of adverse effects. If you have always wanted to try Kratom after being on Suboxone, ensure you switch completely to Kratom. It is also essential to start taking Kratom in small doses. High doses can lead to various unpleasant side effects. If you are suffering from any health conditions, ensure to seek medical advice from your physician about using any of these products.