Top 6 Best Berberine Supplements on the Market: Most Effective Brands to Buy (2024)

Berberine supplements

Made with a naturally occurring bioactive compound called Berberine, Berberine supplements are popular in the healthcare industry. It has gained popularity in the past few years after a breakthrough study revealed that Berberine could be the relief compound for many diseases.

Berberine supplements are a boon for those struggling with life-threatening diabetes, bad cholesterol, and high blood pressure. The supplement is an all-in-one solution for naturally countering these issues and providing better and enhanced health.

Here, we will tell you about the top berberine supplements you can opt for without having any second thoughts.

Top 6 Berberine Supplements You Can Opt For In 2024

Following is the list of the best berberine supplements to achieve balanced blood sugar levels and overall health:

  • Berbamax
  • Barton Nutrition Berberine
  • Double Wood Berberine
  • Liposomal Berberine
  • Thorne Berberine
  • Thrivous Vitality Geroprotector

Berbamax

Berbamax

  • Ingredients Used: Berberine extract, Magnesium stearate, and others.
  • Servings Per Container: 30 servings.
  • Price: It starts at $49.99.
  • Money-Back Guarantee: 14-day money-back guarantee.

Berbamax has been a popular berberine supplement on the market for a while now. Its potent blend of top-quality berberine extract has been labeled as one of the premium options for berberine supplements.

Prepared in a GMP-certified facility, the formula of Berbamax has been curated and finalized by a team of experts who came up with the idea after years of research and studies. Berbamax is not only potent but also highly reliable to be used in the long term.

Every purity standard and safety protocol was followed to the core during production. For the same reasons, it is a fast-acting supplement with significant benefits suiting both men and women.

Another fact that makes it the most-sought option is its ISO verification, gluten-free formula, allergen-free blend, and GMO-free nature.

It is safe for your consumption from all sides and will provide you with immediate results within no time.

Benefits Of Using Berbamax

  • The potent blend of Berbamax helps in regulating healthy blood pressure levels.
  • The natural formula of the berberine supplement supports enhanced cardiovascular health.
  • Berbamax helps in improving and enhancing your digestive system.
  • The supplement helps improve your immune system and protects you from dangerous pathogens or other disease-causing bacteria.
  • Berbamax helps cut down bad cholesterol and replace them with good cholesterol layers.
  • It also supports balanced blood pressure levels and optimizes your overall health.

How Does Berbamax Work?

Made of 97% berberine HCL, Berbamax helps regulate elevated blood sugar levels and improve all other bodily functions. Berberine’s core ingredient has been around for years and has helped several enhance their health with its clinically proven healing properties.

It helps in lowering your glucose level through several methods, i.e., it decreases the insulin resistance of your body by activating the metabolic master switch, which ultimately mobilizes insulin and also improves your metabolic rate. This is the one-way Berbamax controls sugar levels and enhances your metabolism.

Another way it lowers blood glucose is by slowing down the breakdown of carbohydrates. It boosts the thermogenesis process by supporting your liver, suppressing your liver’s tendency to make new glucose cells, and melting away all the bad cholesterol.

Through all this, Berbamax successfully regulates your sugar levels and boosts your overall health.

What Is The Recommended Dosage Of The Supplement?

You are advised to consume one capsule three times a day with food. You can take one dose with your breakfast, the second with your lunch, and the last with your dinner. In this way, you will be able to evenly distribute the consumption and benefit your body in all the possible ways.

Barton Nutrition Berberine

Barton Nutrition Berberine

  • Ingredients Used: Berberine HCL, Milk thistle, Magnesium stearate, Silicon dioxide, Stearic acid, and others.
  • Servings Per Container: 30 servings.
  • Price: It starts at $47.
  • Money-Back Guarantee: 365-day money-back guarantee.

Barton Nutrition Berberine is another popular name on the list, with a mix of potent ingredients that makes it stand out from the crowd. The supplement has gained a vast customer base, given its optimal blend of ingredients and a strong brand reputation.

It is no hidden fact that Barton Nutrition is one of the well-known wellness brands famous for its wide range of natural dietary supplements. For years it has maintained a strong relationship with its customers by preserving their trust, which they have earned by sustaining honesty, transparency, and high-quality supplements.

Manufactured in an FDA-registered facility, this berberine supplement is free from artificial preservatives and has been put under every necessary purity and safety test.

The formula of the Barton Nutrition Berberine is guaranteed and put together by Dr. Scott Saunders, who is the MD. He assures all the users of the dietary supplement with a high level of effectiveness given the super-nutrients inside the blend.

Benefits Of Using Berberine

  • This berberine supplement help in supporting ad regulating healthy blood glucose levels in your body.
  • Barton Nutrition Berberine helps increase and sustain your body’s insulin sensitivity long-term.
  • The supplement helps in fighting against heart complications and keeping your overall heart health safe.
  • It also supports the melting and burning of lousy cholesterol.
  • The natural formula of Berberine also aids and enhances digestion.

How Does Berberine Work?

The advanced formula of Berberine helps supplement your body with all the essential super-nutrients needed for optimal health. This dietary supplement increases your body’s insulin sensitivity and helps keep your glucose levels under strict check.

The formula activates a particular enzyme called AMP-activated protein kinase (AMPK) which helps aid metabolism. When your metabolism is improved, your body tends to metabolize all the unnecessary sugar compounds into energy cells. This way, there is no extra sugar leakage into your blood vessels.

Berberine also works by inhibiting the production of certain enzymes that supports the breakdown of carbohydrates and sugars. This way, your digestion process is smooth, and you can easily balance your blood glucose levels.

What Is The Recommended Dosage Of The Supplement?

As per the creators of the supplement, you are advised to consume two capsules daily. When taken regularly, you can benefit from the nourishing and effective blend of Berberine and balance your blood sugar levels to the maximum potential.

Double Wood Berberine

Double Wood Berberine

  • Ingredients Used: Berberine HCL, Silicon dioxide, and others.
  • Servings Per Container: 60 servings.
  • Price: It starts at $19.95.
  • Money-Back Guarantee: 30-day money-back guarantee.

Made with high-quality berberine extract, Double Wood Berberine has successfully formed a vast customer base over the past few years. The fast-acting yet potent supplement blend has been designed to control your blood sugar and enhance your overall health. Free from any kinds of allergens like soy, dairy, or nuts, Berberine is entirely safe for your intake.

As per many customer reviews, the supplement has provided them ten times better health than any other chemical-infused capsules.

Double Wood has been in the market long enough to build a concrete brand name. Founded by twin brothers in 2013, the brand takes pride in producing some of the best and high-quality wide range of niche and single-ingredient supplements for your brain, immune, and skin health.

For years, it has maintained strict transparency and honesty with all its consumers, and in return, they have made it one of the most-sought healthcare brands in the industry. Their team has curated some of the best dietary supplements, and Berberine is one of their successful results.

Benefits Of Using Berberine

  • Double Wood Berberine helps in supporting and optimizing your cardiovascular health.
  • It helps in enhancing the working of your cognitive functions.
  • The natural formula of Berberine also levels up the healthy cholesterol in your body.

How Does Berberine Work?

The essential and natural formula of Berberine helps regulate your heart health by keeping the blood flow smooth and your glucose levels under control. The supplement provides your body cells with the necessary super-nutrients that help keep them rejuvenated.

The blend cuts down the level of bad cholesterol by triggering the process of fat-burning. This way, your body can have smooth and healthy blood circulation that helps optimize your heart health and cognitive functions.

By controlling the sugar levels by replacing bad cholesterol with healthy ones and freeing blood circulation, the supplement prevents unnecessary damage to your nervous system and keeps them in their best health. This way, you can enjoy the best of everything naturally and effectively.

What Is The Recommended Dosage Of The Supplement?

It is recommended on the official website of Berberine that you should take one capsule two to four times a day along with your meal. It is strictly advised that you should have a gap of at least three hours between the intake of the capsules; otherwise, you can suffer from some gastrointestinal issues.

Liposomal Berberine

Liposomal Berberine

  • Ingredients Used: Berberine, Vegetable cellulose, Rice flour, Sunflower lecithin, and others.
  • Servings Per Container: 90 servings.
  • Price: It starts at $49.50.
  • Money-Back Guarantee: NA.

An advanced supplement available on the market is Liposomal Berberine. Unlike many other berberine supplements, this particular supplement comes with proprietary, powder-based liposomes made up of natural phospholipid molecules that protect Berberine from the effects of digestive enzymes and carry it safely into the bloodstream for targeted delivery.

Founded by Bryan Nettles, Renue by Science was created to provide the world with the highest quality of bioavailable longevity products at an affordable cost. Its wide range of supplements is doctor formulated and fulfills all the necessary safety and purity guidelines.

The supplement contains 150 mg of Lips Berberine in each capsule, prepared using the best quality Berberine. This makes it highly potent and keeps its effectiveness and reliability at its peak. With its daily intake, you can receive significant benefits that will help you hit the health equilibrium in no time.

Benefits Of Using Liposomal Berberine

  • Liposomal Berberine helps in regulating and enhancing your metabolic health.
  • It helps in smoothening the blood circulation in your body and keeping it even.
  • The supplement supports enhanced nutrient absorption in your body.

How Does Liposomal Berberine Work?

Liposomal Berberine works by increasing the nutrient absorption levels in your body and providing you with the best of everything. Daily supplement intake will help you live a better life with better health without compromising on any other factor.

With a smooth blood flow, your body can successfully keep up with all the nutrient supplementation and naturally optimize your overall health.

What Is The Recommended Dosage Of The Supplement?

As per the creators of the berberine supplement, you are advised to consume one capsule daily. The more regular you are with the intake, the more beneficial the supplement will be. It is also recommended to cut down on the high-carb food from your diet and stick to a balanced one to supplement your body with all the necessary nutrients in equal amounts.

Thorne Berberine

Thorne Berberine

  • Ingredients Used: Berberine HCL.
  • Servings Per Container: 30 servings.
  • Price: It starts at $38.
  • Money-Back Guarantee: 60-day money-back guarantee.

Thorne Berberine is a dual-functioning supplement with the goodness of phytosome plus botanical extract. The supplement contains natural Berberine extracts and is rich in essential vitamins and minerals, providing numerous health benefits.

Manufactured after a series of clinical research and trials, the supplement has a fast-acting and potent formula that is safe to consume and helpful for your overall health. The fact that makes this Berberine supplement one of the most in-demand is that it comes from a well-known brand, Thorne.

With a mission to create a happier and healthier life for everyone, Thorne is built-up by a team of healthcare professionals and science experts. They all have worked day and night to manufacture and formulate top-quality supplements that have benefited many users.

Benefits Of Using Thorne Berberine

  • Thorne Berberine helps in keeping your digestive health enhanced.
  • The supplement improves your body’s insulin sensitivity.
  • The berberine supplement promotes healthy and balanced blood sugar levels.
  • It also supports weight management by cutting down on unhealthy cholesterol.
  • The supplement increases good gut bacteria in your body.

How Does Berberine Work?

The highly-absorbable and potent formula of Thorne Berberine works by keeping your blood sugar under control and helping you live a better life. It inhibits excess glucose production by enhancing your digestive health and keeping it intact.

The supplement helps to promote optimal digestion of all the food you consume and converts sugar molecules into energy cells.

This ultimately reduces the level of bad cholesterol in your body and helps increase the good fat layers. Through this, you can control your weight gain and maintain optimal body weight without unnecessary hassles.

What Is The Recommended Dosage Of The Supplement?

You can take one or two capsules twice daily to get the maximum benefit of the berberine supplement. If you want to seek advantages quickly, be regular with its intake.

Also, the supplement is not advisable to be used by pregnant and lactating women. If you are on another medication, seek your physician’s advice before beginning the intake.

Vitality Geroprotector

Vitality Geroprotector

  • Ingredients Used: Berberine HCL, Blueberry fruit extract, Milk thistle fruit extract, Cellulose, Coenzymes, and others.
  • Servings Per Container: 30 servings.
  • Price: It starts at $39.80.
  • Money-Back Guarantee: 100-day money-back guarantee.

Vitality Geroprotector is an all-in-one berberine supplement to help you achieve health benefits. The dietary supplement is one of the best options, prepared with naturally sourced berberine extracts mixed with clinical doses of milk thistle, coenzyme Q10, and others.

Owing to its open-source formula, the supplement combines safe and effective natural geroprotectors in vegan capsules. Coming from a reputable brand, Thrivous, the supplement is safe and reliable from all angles and will help you reach your health peak in no time. The brand has managed excellent transparency with its consumers, making them aware of everything they put inside.

Having passed three levels of rigorous quality control, the supplement has fulfilled all the essential purity criteria. It is prepared in a GMP-certified lab and third-party tested before its public launch.

Benefits Of Vitality Geroprotector

  • Vitality Geroprotector helps in regulating your elevated blood sugar levels.
  • The berberine supplement aids and supports your metabolic health.
  • It enhances your cellular function and helps in keeping you energetic.
  • The supplement also supports healthy genetic functions.

How Does Vitality Geroprotector Work?

Vitality Geroprotector, with its open-source formula, works by controlling your blood sugar levels and supplementing your body cells with all the necessary nutrients. The advanced blend helps enhance your metabolism, leading to better metabolizing sugar molecules into energy cells. With no extra sugar molecules in your body, you can balance your blood glucose level and keep it regulated in the long term.

Besides that, the supplement supports healthy cellular function and better genetic health, promoting healthy aging and keeping you safe from unnecessary health hassles. With regular intake, you can help significant portions of your health and keep them intact in the long term.

What Is The Recommended Dosage Of The Supplement?

As per the official website, you are advised to consume two capsules of the supplement daily with your meals. You can take one with your breakfast and another with your dinner. The company advises its consumers to begin with lower doses of the capsules and then move to higher doses but never exceed the maximum recommended dosage.

This way, you will be able to receive the maximum benefits out of the supplement and heal your overall well-being naturally and effectively. It is also advised to back up your intake with a balanced diet rich in vitamins and essential nutrients and follow a strict workout routine.

Which Ranking Factors Did We Use To Rank The Best Berberine Supplements?

Following are the major ranking factors we considered to rank the best berberine supplements:

Quality Of Ingredients Used

We kept this as our first ranking factor to ensure that all the berberine supplements are of high quality and effectiveness. It is universal knowledge that the efficacy and safety of any supplement depend entirely on the quality of ingredients used to formulate its blend.

Therefore, we have especially handpicked the supplements of high-quality ingredients and had an effective blend. All the berberine supplements ranked here have natural combinations that are safe and fast-acting at the same time.

Effectiveness And Safety

If a supplement is ineffective and has a chance of triggering side effects, it can do more harm than good. We have listed highly effective berberine supplements free from all side effects to counter the same. You can go for any of them and start the journey to maintain your health.

Third-Party Tested

To ensure that supplements are working effectively, it is crucial to conduct third-party testing. Keeping the same in mind, we have kept this as our third ranking factor.

Before their public launch, all the above-listed berberine supplements underwent rigorous purity testing, clinical trials, and third-party testing.

Price And Value

Getting the maximum value for the supplements you invest in is always best. We have made sure of that. Every berberine supplements ranked above are affordable and will give you the maximum value for your investment. They have been tested on various parameters, and the customer satisfaction levels, too, are high.

Customer Testimonials

All the berberine supplements listed above have been rated and reviewed in a very positive light by the majority of their consumers. They are 100% satisfied with their benefits and will help you achieve better health without triggering negative factors. Therefore, feel free to choose any one of them.

Why Do Berberine Supplements Include Berberine HCL?

When you delve deeper into berberine supplements, you may notice that many products listed above contain Berberine HCL instead of regular berberine extract. This section will explore the reasons behind this choice under multiple subheadings:

Enhanced Absorption

One of the primary reasons for including berberine HCL in supplements is its enhanced absorption compared to regular berberine extract. Berberine HCL is a hydrochloride salt form of Berberine, which means it is more soluble in water and has better bioavailability.

This increased solubility allows for better absorption in the gastrointestinal tract, ensuring that a higher percentage of Berberine reaches the bloodstream and exerts its therapeutic effects.

Stability and Shelf Life

Another advantage of Berberine HCL is its stability and extended shelf life. Regular berberine extract is susceptible to degradation when exposed to light, heat, and moisture, which can reduce its potency over time.

On the other hand, berberine HCL is more stable and less prone to degradation, ensuring that the supplement retains its efficacy throughout its shelf life.

This stability is essential for consumers who may not consume the supplement immediately after purchase or store it in less-than-ideal conditions.

Standardization of Dosage

Berberine HCL can be standardized to a specific concentration of Berberine, allowing for accurate and consistent dosing.

This standardization ensures that consumers receive the intended amount of Berberine with each serving, enhancing the reliability and effectiveness of the supplement.

Clinical Research and Efficacy

Many clinical studies on Berberine have used Berberine HCL as the Berberine administered to participants. This choice is often made due to the enhanced absorption and stability of Berberine HCL, which allows for better control and consistency in research settings.

Compliance with Regulatory Standards

Including berberine HCL in supplements also helps ensure compliance with regulatory standards. In some regions, such as the United States, berberine HCL is considered a dietary ingredient and safe for consumption.

On the other hand, regular berberine extract may not have the same regulatory status or approval, making it more challenging for manufacturers to market and sell their products in these regions.

What Other Ingredients Are Added To Berberine Supplements?

Berberine supplements listed above often make sure of various excipients apart from Berberine to offer complementary benefits which are clinically proven as well. Below is an overview of these ingredients:

Blueberry Fruit Extract

One of the main reasons blueberry fruit extract is added to berberine supplements is its rich content of antioxidants. These antioxidants have been shown to reduce inflammation, support cardiovascular health, and improve cognitive function.

In addition to its antioxidant properties, blueberry fruit extract contains many phytochemicals and bioactive compounds. For example, they have been shown to have anti-inflammatory effects, promote healthy aging, and improve insulin sensitivity. B

y combining these bioactive compounds with the beneficial effects of Berberine, the overall impact on health can be amplified.

Milk Thistle Fruit Extract

Milk thistle contains a group of compounds called silymarins which act as a natural antioxidant to protect cells from damage due to free radical molecules.

These silymarins can help boost hepatic metabolism by improving alanine aminotransferase (ALT) levels and helping supply more energy for healthy metabolic rate regulation.

Research indicates that when berberine and milk thistle fruit extract were combined as an oral supplement for 12 weeks, there was evidence of weight reduction along with improved cholesterol levels in 72 obese participants compared to those who only took either one or neither complement separately during this period. This synergy between the two components enabled them to target obesity more effectively.

Cellulose

One of the primary reasons cellulose is added to berberine supplements is to improve their physical properties. These properties make cellulose an ideal excipient for formulating berberine supplements into tablets, capsules, or powders. The supplements gain better compressibility, flowability, and stability by incorporating cellulose.

Furthermore, cellulose acts as a bulking agent, adding volume to the berberine supplements without significantly contributing to their nutritional value. This allows manufacturers to produce larger tablets or capsules containing the desired berberine amount without compromising the dosage accuracy.

It also aids in preventing the formation of clumps or aggregates, ensuring uniform distribution of Berberine throughout the supplement.

Coenzymes

Coenzymes are vital for typical cell function throughout the body. They’re made up of organic molecules which can be transformed into enzymes by activating biochemicals like vitamins B and E.

A study conducted in 2020 showed that combining CoQ10 (an enzyme required by all cells) with Berberine had a significantly more significant impact on weight loss than either supplement taken alone.

Researchers hypothesize that this synergy between different components is caused by Berberine’s priming effects on adipose tissue, allowing cells to absorb CoQ10 better, leading to accelerated fat breakdown and metabolic activation.

Rice Flour

One reason for adding rice flour to berberine supplements is its role as an excipient. An excipient is an inactive ingredient added to a formulation to improve its stability, bioavailability, or other characteristics.

Rice flour acts as a filler in the supplement, ensuring that a consistent amount of Berberine is present in each dose. This is particularly important for capsule or tablet form, as it helps to prevent clumping or uneven distribution of the active ingredient.

The inclusion of rice flour in Berberine supplements enhances absorption. Rice flour contains starch, which is composed of amylose and amylopectin. These complex carbohydrates have been shown to interact with berberine and form inclusion complexes, which can enhance the solubility and stability of Berberine in the gastrointestinal tract.

Sunflower Lecithin

Sunflower lecithin contains essential phospholipids that enhance nutrient absorption from food and regulate metabolism. It helps reduce fat storage by aiding digestion while preventing cholesterol build-up in arteries and veins. Sunflower lecithin also improves cell health, organ function, and the overall health of metabolic pathways.

A study conducted by researchers in 2020 evaluated the effects of combining berberine supplementation with sunflower lecithin.

Participants were divided into two groups – one received just berberine supplementation, while the other received both berberine plus sunflower lecithin supplementation alongside a calorie-reduced diet plan. At the end of the study, it was observed that those taking both compounds experienced significantly more significant decreases in BMI compared to those taking just Berberine alone.

Silicon Dioxide

Silicon dioxide (SiO2) is a compound derived from silica, a mineral found naturally in many foods such as grains, beans, fruits, vegetables, herbs, nuts, and seeds.

In a study conducted at The University of Connecticut’s Health Center research lab, researchers tested the impact of using combined silica/dioxide supplementation alongside 10 mg/kg daily doses of Berberine on metabolic syndrome-related symptoms among 45 overweight individuals living with type 2 diabetes mellitus (T2DM).

The results were compared against baseline measurements obtained before the commencement of the trial period.

After eight weeks, those taking the supplement duo demonstrated significant reductions in BMI -1%, waist circumference – 4 cm., total cholesterol – 7%, triglycerides – 12%, and fasting blood glucose levels -7%.

Magnesium Stearate

One of the primary reasons for incorporating magnesium stearate in berberine supplements is its functionality as a lubricant. During the manufacturing process, various ingredients are mixed to form the final product. The elements can flow more smoothly by adding magnesium stearate, which has excellent lubricating properties, preventing clumping or sticking.

Another important function of magnesium stearate in berberine supplements is its role as an anti-adherent agent. It helps prevent the formation of undesirable aggregates or agglomerates by reducing interparticle friction.

This ensures that each capsule or tablet contains the desired amount of Berberine, providing consistent and accurate dosing for consumers.

What Are The Clinically-Proven Benefits Of Berberine Supplementation?

Below we will explore the clinically-proven benefits of berberine supplementation:

Berberine Helps Boost Weight Loss and Metabolic Function

Berberine is a naturally occurring compound found in herbs such as goldenseal, barberry, and Oregon grape. This alkaloid has been studied for its potential benefits on weight loss and metabolic health.

One of the primary mechanisms by which Berberine may help to promote weight loss is its ability to modulate blood sugar levels. A study published in Metabolism Clinical and Experimental Journal demonstrated that taking 500 mg of Berberine twice daily over 12 weeks reduced fasting glucose levels significantly more than a placebo group.

Berberine improves insulin sensitivity and glucose metabolism, improving blood sugar control and body composition.

Berberine Supplements Help With Detoxification

Berberine has been found to stimulate the activity of various detoxification enzymes, including cytochrome P450 enzymes in the liver, which play a crucial role in the metabolism and elimination of toxins. These enzymes are involved in Phase I detoxification, transforming contamination into intermediate metabolites.

It also helps affect the activity of various transporters involved in this process, such as multidrug resistance-associated proteins (MRPs) and P-glycoprotein (P-gp). By modulating these transporters, Berberine enhances the efflux of toxins from cells, aiding in their elimination.

Berberine Supplementation Helps Improve Muscle Performance

One primary way Berberine improves muscle function is activating an enzyme called AMP-activated protein kinase (AMPK). AMPK is often called the “metabolic master switch” because it regulates cell energy metabolism. When activated, AMPK promotes the uptake and utilization of glucose and fatty acids, increasing muscle cells’ energy production.

In addition to its effects on energy metabolism, Berberine also exerts anti-inflammatory properties. During intense exercise, muscle damage and inflammation can occur, leading to decreased muscle function and delayed recovery.

Berberine has been found to inhibit the activation of inflammatory signaling pathways, reducing inflammation and promoting faster muscle repair and recovery.

Berberine Supplements Can Help Improve Skin Health

Berberine has been shown to benefit skin health and reduce signs of aging.

One study published in 2018 investigated the effects of Berberine on collagen synthesis in human dermal fibroblasts.

The results showed that Berberine could stimulate collagen synthesis significantly more than the control group, indicating its potential for improving skin structure and reducing signs of aging such as wrinkles.

Closing Thoughts On The Best Berberine Supplements

Indeed. Berberine supplements are one of the best healthcare supplements you can invest money on. They are natural and act readily inside your body, providing significant health benefits like balanced blood sugar levels, weight balance, good cholesterol, and enhanced cognitive health.

All the berberine supplements listed in the article will help you achieve the best health without costing too heavily on your bank accounts. You will successfully enjoy better and enhanced health at affordable rates.

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